Contraindicated in:
Use Cautiously in:
Oral
EENT: new/worsening cataracts.
CV: peripheral edema.
GI: PANCREATITIS, abdominal pain, nausea, anorexia, diarrhea, liver function abnormalities, vomiting.
Derm: dry skin, rash, alopecia, exfoliative dermatitis, photosensitivity.
Endo: hyperlipidemia, hypercholesterolemia, hypothyroidism.
Hemat: anemia, leukopenia.
Neuro: headache, weakness, insomnia , headache.
Misc: flu-like syndrome.
Topical
CV: edema.
Derm: pain, pruritus, skin disorder, rash.
Endo: hyperlipidemia.
Hemat: leukopenia.
Misc: lymphadenopathy.
Drug-Drug:
(Generic available)
Absorption: Well absorbed following oral administration, absorption is enhance by a fat-containing meal. Some systemic absorption follows topical application.
Distribution: Unknown.
Protein Binding: >99%.
Metabolism/Excretion: Mostly metabolized by the liver, mainly by the CYP3A4 enzyme system; some metabolites may be pharmacologically active. Excreted almost entirely via hepatobiliary elimination, <1% excreted in urine.
Half-life: 7 hr.
NDC Code*