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Indications ⬇

REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria.

GI: diarrhea, epigastric distress, nausea, vomiting, Clostridioides difficile-associated diarrhea (CDAD).

GU: interstitial nephritis.

Hemat: eosinophilia, leukopenia.

Neuro: SEIZURES.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS) , superinfection.

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

see Calculator

250 mg = 400,000 units

Action ⬆ ⬇

Therapeutic Effects:

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: penicillins

Pharmacokinetics ⬆ ⬇

Absorption: Variably absorbed from the GI tract. Resists acid degradation in the GI tract.

Distribution: Widely distributed, although CNS penetration is poor in the presence of normal (non-inflamed) meninges. Crosses the placenta and enters breast milk.

Protein Binding: 60%.

Metabolism/Excretion: Minimally metabolized by the liver, excreted mainly unchanged by the kidneys.

Half-life: 30–60 min.

Canadian Brand Names ⬆ ⬇

Pen VK

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTEONSETPEAKDURATION
POrapid0.5–1 hr4–6 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

pen-i-SILL-in vee

Code ⬆

NDC Code*