Contraindicated in:
Use Cautiously in:
GI: diarrhea, abdominal distention, abdominal pain, flatulence, gastrointestinal reflux, vomiting.
Neuro: fatigue.
Irritable Bowel Syndrome with Constipation
Chronic Idiopathic Constipation
Functional Constipation
Therapeutic Classification: anti irritable bowel syndrome agents
Pharmacologic Classification: guanylate cyclase-C agonists
Absorption: Minimally absorbed, action is primarily local.
Distribution: Stays within the GI tract with minimal distribution.
Metabolism/Excretion: Converted to its principal active metabolite within the GI tract; subsequently locally degraded to smaller peptides and amino acids; 35% found in stool, mostly as the active metabolite.
Half-life: Unknown.
NDC Code*