Contraindicated in:
Use Cautiously in:
Derm: rash, urticaria.
GI: diarrhea, epigastric distress, nausea, vomiting, ↑ liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD).
GU: acute kidney injury, hematuria, interstitial nephritis, proteinuria.
Hemat: eosinophilia, leukopenia.
Local: pain at IM site, phlebitis at IV site.
Neuro: SEIZURES.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS), superinfection.
Drug-Drug:
(Generic available)
Spectrum:
Therapeutic Classification: anti-infectives
Pharmacologic Classification: penicillinase resistant penicillins
Absorption: Completely absorbed following IV administration; well absorbed from IM sites.
Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.
Protein Binding: 90% to albumin.
Metabolism/Excretion: Partially metabolized by the liver (60%), partially excreted unchanged by the kidneys.
Half-life: Neonates: 1–5 hr; Children 1 mo – 14 yr: 0.75–1.9 hr; Adults: 0.5–1.5 hr (increased in renal impairment).
NDC Code*
