Peginterferon alpha-2a:
Interferon alpha-n3:
Contraindicated in:
Use Cautiously in:
Exercise Extreme Caution in:
All are more prominent with SUBQ, IV, or IM administration
CV: edema, arrhythmias, chest pain, heart block, ISCHEMIC DISORDERS.
Derm: alopecia, dry skin, pruritus, rash, sweating.
EENT: nose bleeds, rhinitis, blurred vision.
Endo: ↓ growth (children), thyroid disorders.
GI: ↑ liver enzymes, abdominal pain, anorexia, diarrhea, dry mouth, nausea, taste disorder, vomiting, weight loss, COLITIS, flatulence, HEPATOTOXICITY, PANCREATITIS.
Hemat: anemia, hemolytic anemia (with ribavirin), leukopenia, thrombocytopenia.
Local: injection site reactions.
MS: arthralgia, myalgia, leg cramps.
Neuro: confusion, depression, dizziness, fatigue, headache, insomnia, irritability, aggression, anxiety , HOMICIDAL IDEATION, paresthesia, SUICIDAL IDEATION/ATTEMPTS.
Misc: chills, fever, flu-like syndrome, AUTOIMMUNE DISORDERS, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), INFECTION.
Drug-Drug:
Peginterferon Alpha-2a
Interferon Alpha-n3
Peginterferon Alpha-2a
Renal Impairment
Interferon Alpha-n3
Absorption: Well absorbed (>80%) following IM and SUBQ administration. Minimal systemic absorption follows intralesional administration.
Distribution: Unknown.
Metabolism/Excretion: Filtered by the kidneys and subsequently degraded in the renal tubule.
Half-life: Peginterferon alpha-2a: 50160 hr;.
(clinical effects)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
Interferon alpha-n3 | unknown | 48 wk | unknown (IL) |
IL= regression of lesions.