Contraindicated in:
Use Cautiously in:
CNS: SEIZURES.
GI: diarrhea, epigastric distress, nausea, vomiting, Clostridium difficile-associated diarrhea (CDAD).
GU: interstitial nephritis.
Derm: rash, urticaria.
Hemat: eosinophilia, leukopenia.
Local: pain at IM site, phlebitis at IV site.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS AND SERUM SICKNESS, superinfection.
Drug-Drug:
40 kg): 250–2000 mg q 4–6 hr (up to 12 g/day).2 kg): — 75 mg/kg/day divided q 8 hr for the first 7 days of life, then 100 mg/kg/day divided q 6 hr.Spectrum:
Therapeutic Classification: anti-infectives
Pharmacologic Classification: penicillinase resistant penicillins
Absorption: Completely absorbed following IV administration; well absorbed from IM sites.
Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.
Protein Binding: 94% to albumin.
Metabolism/Excretion: Partially metabolized by the liver (9%), partially excreted unchanged by the kidneys.
Half-life: Neonates: 1.6 hr; Children up to 2 yr: 0.9–1.8 hr; Adults: 0.3–0.8 hr (↑ in severe hepatic impairment).
NDC Code*
