- PO (Adults): 12.5–37.5 mg/kg every 6 hr.
- PO (Children): 12.5–37.5 mg/kg every 6 hr.
Renal Impairment
- PO (Adults): CCr 20–40 mL/min: 12.5 mg/kg every 12 hr; CCr 10–20 mL/min: 12.5 mg/kg every 24 hr; CCr <10 mL/min: 12.5 mg/kg every 24–48 hr.
Contraindicated in:
Use Cautiously in:
Exercise Extreme Caution in:
CV: chest pain.
Derm: photosensitivity, pruritus, rash, urticaria.
EENT: hearing loss.
Endo: hypoglycemia.
F and E: hypokalemia.
GI: diarrhea, nausea, vomiting, abdominal pain, dry mouth.
GU: azotemia.
Hemat: leukopenia, pancytopenia, anemia, APLASTIC ANEMIA, eosinophilia, thrombocytopenia.
Neuro: dizziness, ataxia, confusion, drowsiness, fatigue, headache, peripheral neuropathy, SEIZURES.
Resp: dyspnea.
Misc: fever.
Drug-Drug:
Renal Impairment
Spectrum:
Absorption: Well absorbed (80–90%) from the GI tract following oral administration.
Distribution: Widely distributed. Crosses the blood-brain barrier.
Metabolism/Excretion: Undergoes minimal hepatic metabolism; deaminated by gut bacteria to 5–fluorouracil (metabolized by dihydopyrimidine dehydrogenase); 80–90% excreted unchanged by the kidneys.
Half-life: 2.5–5 hr (↑ in renal impairment).
NDC Code*
