pi-o-GLIT-a-zone 
Contraindicated in:
Use Cautiously in:
CV: HF, edema.
EENT: macular edema.
GI: LIVER FAILURE, ↑ liver enzymes.
GU: BLADDER CANCER.
Hemat: anemia.
MS: RHABDOMYOLYSIS, fractures (arm, hand, foot) (females).
Drug-Drug:
Drug-Natural Products:
(Generic available)
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: >99% bound to plasma proteins. Active metabolites are also highly (>99%) bound.
Metabolism/Excretion: Extensively metabolized by the liver (primarily by CYP2C8); at least two metabolites have pharmacologic activity. Minimal renal excretion of unchanged drug.
Half-life: Pioglitazone — 3–7 hr; total pioglitazone (pioglitazone plus metabolites) — 16–24 hr.
NDC Code*
