zoe-led-DRON-ic AS-id 
Contraindicated in:
Use Cautiously in:
CV: hypotension, chest pain, leg edema.
Derm: pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
EENT: conjunctivitis.
F and E: hypophosphatemia, hypocalcemia, hypokalemia, hypomagnesemia.
GI: abdominal pain, constipation, diarrhea, nausea, vomiting, dysphagia.
GU: ↓ fertility (females), renal impairment/failure.
Hemat: anemia.
MS: musculoskeletal pain, femur fractures, osteonecrosis (primarily ONJ).
Neuro: agitation, anxiety, confusion, insomnia.
Resp: asthma exacerbation.
Misc: fever, flu-like syndrome.
Drug-Drug:
Paget's Disease
Treatment of Osteoporosis in Men or Postmenopausal Women or Treatment/Prevention of Glucocorticoid-Induced Osteoporosis
Prevention of Osteoporosis in Postmenopausal Women
Hypercalcemia of Malignancy
Multiple Myeloma or Bone Metastases from Solid Tumors
Therapeutic Classification: bone resorption inhibitors, electrolyte modifiers, hypocalcemics
Pharmacologic Classification:
Absorption: IV administration results in complete bioavailability.
Distribution: Concentrated in and binds to bone.
Metabolism/Excretion: Mostly excreted unchanged by the kidneys.
Half-life: 167 hr.
NDC Code*