- PO (Adults and Children
40 kg): 125–250 mg q 6 hr (up to 2 g/day). - PO (Children <40 kg): 25–50 mg/kg/day divided q 6 hr; (up to 50–100 mg/kg/day divided q 6 hr has been used for osteomyelitis), maximum: 2 g/day.
Contraindicated in:
Use Cautiously in:
CNS: SEIZURES.
GI: CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, epigastric distress, nausea, vomiting, ↑ liver enzymes.
GU: interstitial nephritis.
Derm: rash, urticaria.
Hemat: eosinophilia, leukopenia.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS AND SERUM SICKNESS, superinfection.
Drug-Drug:
40 kg): 125–250 mg q 6 hr (up to 2 g/day).Spectrum:
Therapeutic Classification: anti-infectives
Pharmacologic Classification: penicillinase resistant penicillins
Absorption: Rapidly but incompletely (35–76%) absorbed from the GI tract.
Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.
Protein Binding: 96–98%.
Metabolism/Excretion: Some metabolism by the liver (6–10%) and some renal excretion of unchanged drug (60%); small amounts eliminated in the feces via the bile.
Half-life: 0.5–1 hr (↑ in severe hepatic and renal dysfunction).
NDC Code*
