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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: dizziness, headache, drowsiness.

EENT: blurred vision, tinnitus.

CV: HF, MYOCARDIAL INFARCTION, STROKE, edema, hypertension.

GI: GI BLEEDING, DRUG-INDUCED HEPATITIS, constipation, diarrhea, discomfort, dyspepsia, nausea, vomiting, anorexia, flatulence, pancreatitis.

GU: renal failure.

Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, rash, photosensitivity.

Hemat: blood dyscrasias, prolonged bleeding time.

Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS AND HYPERSENSITIVITY SYNDROME.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Clinoril

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antirheumatics, nonsteroidal anti-inflammatory agents

Pharmacokinetics

Absorption: Well absorbed from the GI tract after oral administration.

Distribution: Unknown. Enters breast milk in small amounts.

Metabolism/Excretion: Converted by the liver to active drug. Minimal amounts excreted unchanged by the kidneys.

Half-life: 7.8 hr (16.4 hr for active metabolite).

Time/Action Profile

ROUTEONSETPEAKDURATION
PO (analgesic)1–2 daysunknown12 hr
PO (anti-inflammatory)few days–1 wk2 wk or moreunknown

Patient/Family Teaching

Pronunciation

SOO-lin-dak audio

Code

NDC Code*