Contraindicated in:
Use Cautiously in:
CV: TORSADES DE POINTES.
GI: abdominal pain, nausea, ↑ liver enzymes, change in appetite, vomiting.
GU: chromaturia.
Hemat: AGRANULOCYTOSIS, neutropenia.
MS: arthralgia, arthropathy, back pain, extremity pain.
Neuro: headache.
Misc: ↓ zinc levels.
Drug-Drug:
(Generic available)
Twice Daily Regimen
Three Times Daily Regimen
Absorption: Well absorbed following oral administration.
Distribution: Widely distributed to extravascular tissues.
Metabolism/Excretion: Mostly metabolized (by UGT1A6 enzyme system), 7590% excreted in urine as metabolites.
Half-life: 1.9 hr.
NDC Code*