• Treatment of diarrhea due to Cryptosporidium parvum and Giardia lamblia.
• Not effective for C. parvum diarrhea in patients infected with HIV.

Contraindicated in:

• Hypersensitivity.

Use Cautiously in:

• Hepatic or renal impairment
• Diabetes (contains 1.48 g sucrose/5 mL)
• OB: Safety not established in pregnancy
• Lactation: Safety not established in breastfeeding
• Pedi: Children <1 yr (safety and effectiveness not established).

Derm: pruritus, sweating.

EENT: yellow eye discoloration.

GI: abdominal pain, diarrhea, vomiting.

GU: discolored urine.

Neuro: dizziness.

Misc: fever.

Drug-Drug:

• May interact with other highly protein-bound drugs by competing for binding sites.

(Generic available)

• Tablets: 500 mg ;
• Oral suspension (strawberry): 100 mg/5 mL;

• PO (Adults and Children ≥12 yr): 500 mg every 12 hr for 3 days (as tablets or oral suspension).
• PO (Children 4–11 yr): 200 mg every 12 hr for 3 days (as oral suspension).
• PO (Children 1–4 yr): 100 mg every 12 hr for 3 days (as oral suspension).

Alinia

• Interferes with electron transfer reaction necessary for anaerobic energy metabolism of offending organisms.

• Antiprotozoal action resulting in decreased diarrhea.

Therapeutic Classification: antiprotozoals

Pharmacologic Classification: benzamides

Absorption: Following oral administration, nitazoxanide is rapidly converted to tizoxanide which is the active metabolite; tizoxanide is further metabolized.

Distribution: Unknown.

Protein Binding: >99%.

Metabolism/Excretion: Tizoxanide: excreted in urine, bile and feces; inactive metabolites excreted in urine, bile and feces.

Half-life: Unknown.

(blood levels)

†Onset of antidiarrheal activity is 24–48 hr.

• Explain to parents administration of medication and monitoring of condition.
• Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

nit-a-ZOX-a-nide

NDC Code^*

• 67546- Romark Laboratories, L.C.
  • 67546-111- Alinia
    • 67546-111-12- 1 BOTTLE, PLASTIC in 1 CARTON (67546-111-12) > 30 TABLET in 1 BOTTLE, PLASTIC

• 67546- Romark Laboratories, L.C.
  • 67546-111- Alinia
    • 67546-111-14- 1 BOTTLE, PLASTIC in 1 CARTON (67546-111-14) > 12 TABLET in 1 BOTTLE, PLASTIC

• 67546- Romark Laboratories, L.C.
  • 67546-212- Alinia
    • 67546-212-21- 1 BOTTLE, GLASS in 1 CARTON (67546-212-21) > 60 mL in 1 BOTTLE, GLASS