Contraindicated in:
Use Cautiously in:
CV: hypertension, peripheral edema, tachycardia.
Derm: ↑ sweating, erythema multiforme, urticaria.
EENT: blurred vision, impaired vision, mydriasis, photophobia, rhinorrhea, unequal pupils.
Endo: hyperglycemia, hypoglycemia.
F and E: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia, hypophosphatemia.
GI: ↑ liver enzymes, constipation, diarrhea, hypoalbuminemia, nausea, vomiting.
GU: urinary retention.
Hemat: anemia, lymphocytopenia, neutropenia, thrombocytopenia.
Local: injection site reaction.
Metab: ↓ appetite, ↓ weight.
Neuro: anxiety, fatigue, headache, irritability, neuropathic pain, peripheral neuropathy, sedation, POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME (PRES), transverse myelitis.
Resp: cough.
Misc: fever, infusion reactions, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS).
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Metabolized into small peptides.
Half-life: 8.2 days.