OIC in Patients with Advanced Illness
- SC (Adults): 38<62 kg 8 mg every other day, not to exceed every 24 hr; 62114 kg 12 mg every other day, not to exceed every 24 hr; >114 kg 0.15 mg/kg every other day, not to exceed every 24 hr.
Renal Impairment
(Adults): CCr <60 mL/min use 50% of recommended dose based on weight.
OIC in Patients with Non-Cancer Pain
- SC (Adults): 12 mg once daily.
Renal Impairment
- SC (Adults): CCr <60 mL/min 6 mg once daily.
Hepatic Impairment
- SC (Adults): Severe hepatic impairment (ChildPugh Class C) <38 kg: 0.075 mg/kg once daily; 38<62 kg: 4 mg once daily; 62114 kg: 6 mg once daily: >114 kg: 0.075 mg/kg once daily.
- PO (Adults): 450 mg once daily.
Renal Impairment
- PO (Adults): CCr <60 mL/min 150 mg once daily.
Hepatic Impairment
- PO (Adults): Moderate or severe hepatic impairment (ChildPugh Class B or C) 150 mg once daily.
Therapeutic Classification: laxatives
Pharmacologic Classification: opioid antagonists
Absorption: Rapidly absorbed after subcutaneous and oral administration; oral absorption delayed by high-fat meal by 2 hr.
Distribution: Moderate tissue distribution, does not cross the blood-brain barrier.
Metabolism/Excretion: Some metabolism; 85% excreted unchanged in urine.
Half-life: 15 hr (oral).
methylnaltrexone: me-thil-nal-TREX-one