Contraindicated in:
Use Cautiously in:
CV: peripheral edema, CARDIAC TAMPONADE, PERICARDIAL EFFUSION.
Derm: alopecia, edema, rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP), dermatitis, desquamation, erythema, nail disorders, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN).
EENT: cystoid macular edema.
GI: diarrhea, nausea, stomatitis, vomiting, ASCITES, ENTEROCOLITIS, NEUTROPENIC COLITIS.
GU: ↓ fertility (males), amenorrhea.
Hemat: anemia, leukopenia, thrombocytopenia.
Local: injection site reactions.
MS: myalgia, arthralgia.
Neuro: fatigue, weakness, alcohol intoxication, neurosensory deficits, peripheral neuropathy.
Resp: ACUTE RESPIRATORY DISTRESS SYNDROME, bronchospasm, dyspnea, INTERSTITIAL LUNG DISEASE, PULMONARY EDEMA, PULMONARY FIBROSIS.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), MALIGNANCY (INCLUDING LEUKEMIAS, MYELODYSPLASTIC SYNDROME, NON-HODGKIN'S LYMPHOMA, AND RENAL CANCER), tumor lysis syndrome.
Drug-Drug:
(Generic available)
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Metabolism/Excretion: Extensively metabolized by the liver via the CYP3A isoenzyme; metabolites undergo fecal elimination.
Half-life: 116 hr.
NDC Code*
