- IV (Adults and Children): 10 mg/kg just prior to surgery with appropriate replacement therapy, then 10 mg/kg 3–4 times daily for 2–8 days.
Renal Impairment
- IV (Adults and Children): SCr 1.36–2.83 mg/dL — 10 mg/kg twice daily; SCr 2.83–5.66 mg/dL — 10 mg/kg daily; SCr >5.66 mg/dL — 10 mg/kg every 48 hr or 5 mg/kg once daily.
- PO (Adults): 1300 mg 3 times daily for a maximum of 5 days during menstruation.
Renal Impairment
- PO (Adults): SCr 1.41–2.8 mg/dL–1300 mg twice daily for a maximum of 5 days during menstruation; SCr 2.81–5.7 mg/dL–1300 mg daily for a maximum of 5 days during menstruation; SCr >5.7 mg/dL–650 mg daily for a maximum of 5 days during menstruation;.
