Malaria
- PO (Adults): Prophylaxis: 400 mg once weekly; start 2 wk prior to entering malarious area; continue for 4 wk after leaving area. Treatment: 800 mg initially, then 400 mg at 6 hr, 24 hr, and 48 hr after initial dose.
- PO (Children ≥31 kg): Prophylaxis: 6.5 mg/kg (not to exceed 400 mg) once weekly; start 2 wk prior to entering malarious area; continue for 4 wk after leaving area. Treatment: 13 mg/kg (not to exceed 800 mg) initially, then 6.5 mg/kg (not to exceed 400 mg) at 6 hr, 24 hr, and 48 hr after initial dose.
Rheumatoid Arthritis
- PO (Adults): 400–600 mg per day in 1–2 divided doses; once adequate response obtained, may ↓ dose to maintenance dose of 200–400 mg per day in 1–2 divided doses.
Lupus Erythematosus
- PO (Adults): 200–400 mg per day in 1–2 divided doses.
