• Management of symptomatic benign prostatic hyperplasia (BPH).

Contraindicated in:

• Hypersensitivity
• Moderate to severe hepatic impairment
• Concurrent use of strong CYP3A4 inhibitors
• Concurrent use of other alpha-adrenergic blocking agents
• Severe renal impairment

Use Cautiously in:

• Congenital or acquired QTc prolongation or concurrent use of other drugs known to prolong QTc
• Mild hepatic impairment
• Symptomatic hypotension
• Concurrent use of antihypertensive agents, phosphodiesterase type 5 inhibitors, or nitrates (↑ risk of postural hypotension)
• Previous hypotensive episode with other medications
• Geri: Consider age-related changes in body mass and cardiac, renal, and hepatic function when prescribing in older adults.

CV: postural hypotension.

Derm: TOXIC EPIDERMAL NECROLYSIS.

EENT: intraoperative floppy iris syndrome.

GI: abdominal pain, constipation, dyspepsia, nausea.

GU: erectile dysfunction, priapism.

Hemat: thrombocytopenia.

Neuro: dizziness, fatigue, headache.

Resp: bronchitis, pharyngitis, sinusitis.

Drug-Drug:

• Strong CYP3A4 inhibitors, including ketoconazole, itraconazole, and ritonavir, may significantly ↑ levels and risk of toxicity; concurrent use contraindicated.
• Cimetidine, atenolol, and diltiazem may ↑ levels and risk of toxicity.
• May ↑ levels and risk of toxicity of atenolol and diltiazem; monitor BP and heart rate.
• ↑ risk of hypotension with antihypertensives, nitrates, phosphodiesterase type 5 inhibitors (including sildenafil, tadalafil, and vardenafil) and acute ingestion of alcohol.

(Generic available)

• Extended-release tablets: 10 mg;

• PO (Adults): 10 mg once daily.

Uroxatral

• Selectively blocks alpha₁-adrenergic receptors in the lower urinary tract to relax smooth muscle in the bladder neck and prostate.

• Increased urine flow and decreased symptoms of BPH.

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: peripherally acting antiadrenergics

Absorption: 49% absorbed following oral administration; food enhances absorption.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP3A4 isoenzyme system; 11% excreted unchanged in urine.

Half-life: 10 hr.

Xatral

• Instruct patient to take medication with the same meal each day. Take missed doses as soon as remembered. If not remembered until next day, omit; do not double doses.
  • May cause dizziness or drowsiness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
  • Caution patient to avoid sudden changes in position to decrease orthostatic hypotension.
  • Advise patient to consult health care professional before taking any cough, cold, or allergy remedies.
  • Instruct patient to notify health care professional of medication regimen before any surgery, especially cataract surgery.
  • Advise patient to notify health care professional if priapism, angina, frequent dizziness, rash, or fainting occurs.
  • Emphasize the importance of follow-up exams to evaluate effectiveness of medication.
  • Geri: Assess risk for falls; implement fall prevention program and instruct patient and family in preventing falls at home.

al-FYOO-zo-sin

NDC Code^*

• 13668- Torrent Pharmaceuticals Limited
  • 13668-021- ALFUZOSIN HYDROCHLORIDE
    • 13668-021-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-01)

• 13668- Torrent Pharmaceuticals Limited
  • 13668-021- ALFUZOSIN HYDROCHLORIDE
    • 13668-021-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-05)

• 13668- Torrent Pharmaceuticals Limited
  • 13668-021- ALFUZOSIN HYDROCHLORIDE
    • 13668-021-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-30)

• 13668- Torrent Pharmaceuticals Limited
  • 13668-021- ALFUZOSIN HYDROCHLORIDE
    • 13668-021-64- 90 TABLET, EXTENDED RELEASE in 1 DOSE PACK (13668-021-64)

• 29300- Unichem Pharmaceuticals (USA), Inc.
  • 29300-155- Alfuzosin hydrochloride
    • 29300-155-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-01)

• 29300- Unichem Pharmaceuticals (USA), Inc.
  • 29300-155- Alfuzosin hydrochloride
    • 29300-155-13- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-13)

• 29300- Unichem Pharmaceuticals (USA), Inc.
  • 29300-155- Alfuzosin hydrochloride
    • 29300-155-19- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-19)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-994- Alfuzosin Hydrochloride
    • 33261-994-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-30)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-994- Alfuzosin Hydrochloride
    • 33261-994-60- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-60)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-994- Alfuzosin Hydrochloride
    • 33261-994-90- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-90)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-746- Alfuzosin Hydrochloride
    • 43353-746-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (43353-746-30)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-746- Alfuzosin Hydrochloride
    • 43353-746-60- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (43353-746-60)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-945- Alfuzosin hydrochloride
    • 43353-945-16- 6000 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-16)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-945- Alfuzosin hydrochloride
    • 43353-945-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-30)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-945- Alfuzosin hydrochloride
    • 43353-945-60- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-60)

• 47335- Sun Pharmaceutical Industries, Inc.
  • 47335-956- Alfuzosin Hydrochloride
    • 47335-956-08- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-08)

• 47335- Sun Pharmaceutical Industries, Inc.
  • 47335-956- Alfuzosin Hydrochloride
    • 47335-956-18- 1000 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-18)

• 47335- Sun Pharmaceutical Industries, Inc.
  • 47335-956- Alfuzosin Hydrochloride
    • 47335-956-81- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-81)

• 47335- Sun Pharmaceutical Industries, Inc.
  • 47335-956- Alfuzosin Hydrochloride
    • 47335-956-83- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-83)

• 47335- Sun Pharmaceutical Industries, Inc.
  • 47335-956- Alfuzosin Hydrochloride
    • 47335-956-88- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-88)

• 55648- Wockhardt Limited
  • 55648-738- Alfuzosin Hydrochloride
    • 55648-738-01- 30 TABLET in 1 BOTTLE (55648-738-01)

• 55648- Wockhardt Limited
  • 55648-738- Alfuzosin Hydrochloride
    • 55648-738-02- 100 TABLET in 1 BOTTLE (55648-738-02)

• 55648- Wockhardt Limited
  • 55648-738- Alfuzosin Hydrochloride
    • 55648-738-03- 500 TABLET in 1 BOTTLE (55648-738-03)

• 55648- Wockhardt Limited
  • 55648-738- Alfuzosin Hydrochloride
    • 55648-738-05- 10 BLISTER PACK in 1 CARTON (55648-738-05) > 10 TABLET in 1 BLISTER PACK

• 57237- Rising Health, LLC
  • 57237-114- Alfuzosin Hydrochloride
    • 57237-114-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-01)

• 57237- Rising Health, LLC
  • 57237-114- Alfuzosin Hydrochloride
    • 57237-114-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-05)

• 57237- Rising Health, LLC
  • 57237-114- Alfuzosin Hydrochloride
    • 57237-114-90- 90 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-90)

• 59212- Concordia Pharmaceuticals Inc.
  • 59212-200- Uroxatral
    • 59212-200-10- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (59212-200-10)

• 59212- Concordia Pharmaceuticals Inc.
  • 59212-200- Uroxatral
    • 59212-200-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (59212-200-30)

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-0- 10 BLISTER PACK in 1 CARTON (60505-2850-0) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-1- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-1)

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-3- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-3)

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-5- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-5)

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-7- 8000 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-7)

• 60505- Apotex Corp.
  • 60505-2850- Alfuzosin Hydrochloride
    • 60505-2850-8- 1000 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-8)

• 63629- Bryant Ranch Prepack
  • 63629-7907- Alfuzosin hydrochloride
    • 63629-7907-1- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (63629-7907-1)

• 64679- Wockhardt USA LLC.
  • 64679-738- Alfuzosin Hydrochloride
    • 64679-738-01- 30 TABLET in 1 BOTTLE (64679-738-01)

• 64679- Wockhardt USA LLC.
  • 64679-738- Alfuzosin Hydrochloride
    • 64679-738-02- 100 TABLET in 1 BOTTLE (64679-738-02)

• 64679- Wockhardt USA LLC.
  • 64679-738- Alfuzosin Hydrochloride
    • 64679-738-03- 500 TABLET in 1 BOTTLE (64679-738-03)

• 64679- Wockhardt USA LLC.
  • 64679-738- Alfuzosin Hydrochloride
    • 64679-738-05- 10 BLISTER PACK in 1 CARTON (64679-738-05) > 10 TABLET in 1 BLISTER PACK

• 65862- Aurobindo Pharma Limited
  • 65862-249- Alfuzosin Hydrochloride
    • 65862-249-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-01)

• 65862- Aurobindo Pharma Limited
  • 65862-249- Alfuzosin Hydrochloride
    • 65862-249-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-05)

• 65862- Aurobindo Pharma Limited
  • 65862-249- Alfuzosin Hydrochloride
    • 65862-249-30- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-30)

• 65862- Aurobindo Pharma Limited
  • 65862-249- Alfuzosin Hydrochloride
    • 65862-249-90- 90 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-90)

• 65862- Aurobindo Pharma Limited
  • 65862-249- Alfuzosin Hydrochloride
    • 65862-249-99- 1000 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-99)

• 69097- Cipla USA Inc.
  • 69097-844- Alfuzosin Hydrochloride extended release
    • 69097-844-02- 30 TABLET in 1 BOTTLE (69097-844-02)

• 69097- Cipla USA Inc.
  • 69097-844- Alfuzosin Hydrochloride extended release
    • 69097-844-05- 90 TABLET in 1 BOTTLE (69097-844-05)

• 69097- Cipla USA Inc.
  • 69097-844- Alfuzosin Hydrochloride extended release
    • 69097-844-07- 100 TABLET in 1 BOTTLE (69097-844-07)

• 69097- Cipla USA Inc.
  • 69097-844- Alfuzosin Hydrochloride extended release
    • 69097-844-12- 500 TABLET in 1 BOTTLE (69097-844-12)

• 70934- Denton Pharma, Inc. DBA Northwind Pharmaceuticals
  • 70934-306- Alfuzosin Hydrochloride
    • 70934-306-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (70934-306-30)

• 76282- Exelan Pharmaceuticals Inc.
  • 76282-302- Alfuzosin hydrochloride
    • 76282-302-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-01)

• 76282- Exelan Pharmaceuticals Inc.
  • 76282-302- Alfuzosin hydrochloride
    • 76282-302-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-05)

• 76282- Exelan Pharmaceuticals Inc.
  • 76282-302- Alfuzosin hydrochloride
    • 76282-302-90- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-90)