• Cleansing of the colon in preparation for colonoscopy.

Contraindicated in:

• Hypersensitivity
• GI obstruction/ileus/bowel perforation/toxic colitis or megacolon/gastric retention.

Use Cautiously in:

• Renal impairment/concurrent medications affecting renal function (↑ risk of renal impairment)
• Known risk factors for arrhythmias including prolonged QT interval, recent MI, unstable angina pectoris, HF, or cardiomyopathy
• Known/suspected inflammatory bowel disease (may cause mucosal ulcerations)
• Electrolyte abnormalities (correct prior to administration)
• History of seizures or concurrent use of medications that ↓ seizure threshold (may ↑ risk of seizures)
• Gout (may ↑ uric acid levels)
• Patients at risk for aspiration
• OB: Use during pregnancy only if clearly needed
• Lactation: Use caution if breast feeding
• Pedi: Safety and effectiveness not established.

CNS: SEIZURES, headache.

CV: ARRHYTHMIAS.

Endo: hyperuricemia.

GI: abdominal distention, abdominal pain, nausea, hyperbilirubinemia, vomiting.

GU: RENAL IMPAIRMENT.

F and E: hypercalcemia, dehydration.

Drug-Drug:

• Concurrent use of drugs affecting fluid and electrolyte status/renal function, including ACE inhibitors, angiotensin receptor blockers, corticosteroids, NSAIDs, diuretics, and other laxatives may ↑ risk of dehydration, renal impairment, seizures, hypotension, and fluid/electrolyte abnormalities.
• Concurrent use of medications that ↓ seizure threshold, including tricyclic antidepressants or concurrent alcohol/ benzodiazepine withdrawal (may ↑ risk of seizures).
• Oral medications taken within 1 hr of start may not be properly absorbed.
• Concurrent use of other laxatives may ↑ risk of mucosal ulcerations.
• May ↑ risk of digoxin toxicity in the presence of electrolyte abnormalities.

• Powder for oral use (requires reconstitution) (lemon): 17.5 g sodium sulfate/3.13 g potassium sulfate/1.6 g magnesium sulfate per bottle;

• PO (Adults): One bottle during evening before colonoscopy (10–12 hr before second dose), repeated during the morning prior to the colonoscopy (3.5 hr before colonoscopy). Additional clear liquids are required after each dose.

Colprep Kit, Suprep Bowel Prep Kit

• Unabsorbed cations and anions in the GI tract cause osmotic laxative effect by causing water retention in the GI tract.

• With concurrent fluid ingestion, produces watery diarrhea and colonic purging in preparation for colonoscopy.

Therapeutic Classification: laxatives

Pharmacologic Classification: osmotics

Absorption: Minimal systemic absorption.

Distribution: Action is primarily local.

Metabolism/Excretion: Not metabolized; primarily eliminated via fecal excretion.

Half-life: 8.5 hr.

(onset of watery diarrhea)

• Instruct patient in correct technique for preparing and taking prep kit. Solution must be diluted as directed; ingestion of undiluted solution may increase risk of nausea, vomiting, and dehydration.
• Advise patient to hydrate adequately before, during, and after prep. Advise patient to expect watery diarrhea after ingesting prep kit.
• Inform patients to avoid taking other oral medications within 1 hr of each dose of prep kit; they may not be absorbed.
• Instruct patient to avoid taking other laxatives while taking prep kit.
• Advise female patient to notify health care professional if pregnancy is planned or suspected or if breast feeding.

SOE-dee-um SUL-fate/poe-TASS-ee-um SUL-fate/mag-NEE-zhum SUL-fate