Contraindicated in:
Use Cautiously in:
Derm: photosensitivity, rash, palmar-plantar erythrodysaesthesia syndrome, pruritus.
Endo: hypercholesterolemia.
GI: ↓ appetite, ↑ liver function tests, abdominal pain, constipation, diarrhea, nausea, vomiting.
GU: ↑ serum creatinine.
Hemat: anemia, lymphocytopenia, neutropenia, thrombocytopenia, MYELODYSPLASTIC SYNDROME/ACUTE MYELOID LEUKEMIA.
Neuro: dizziness, dysgeusia, fatigue.
Resp: dyspnea.
Misc: fever.
Drug-Drug:
Absorption: 3045% absorbed following oral administration; bioavailability increased but delayed with high-fat meal.
Distribution: Extensively distributed to tissues.
Metabolism/Excretion: Extensively metabolized primarily by the CYP2D6 isoenzyme and to a lesser extent by the CYP1A2 and CYP3A4 isoenzymes; information regarding mode of elimination unknown.
Half-life: 1719 hr.
NDC Code*