Contraindicated in:
Use Cautiously in:
CV: chest pain.
Derm: alopecia, rash.
F and E: hyponatremia.
GI: constipation, nausea, ↑ in liver enzymes, abdominal pain, anorexia, diarrhea, vomiting.
Hemat: anemia, neutropenia, thrombocytopenia.
Local: irritation at IV site, phlebitis.
MS: arthralgia, back pain, jaw pain, myalgia.
Neuro: fatigue, neurotoxicity.
Resp: shortness of breath.
Drug-Drug:
Hepatic Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: Highly bound to platelets and lymphocytes.
Metabolism/Excretion: Mostly metabolized by the liver. At least one metabolite is active. Large amounts eliminated in feces; 11% excreted unchanged by the kidneys.
Half-life: 2844 hr.
NDC Code*