Contraindicated in:
Use Cautiously in:
Derm: alopecia, erythema, maculopapular rash.
Endo: gonadal suppression.
GI: bleeding, diarrhea, gastritis, nausea, stomatitis, vomiting, anorexia, ulcer.
Hemat: anemia, leukopenia, thrombocytopenia.
Neuro: fatigue, headache.
Misc: fever.
Drug-Drug:
Absorption: Administered intra-arterially only, resulting in direct delivery to tumor sites.
Distribution: Distributes mostly to tumor site as a result of elective intra-arterial administration.
Metabolism/Excretion: Rapidly converted to floxuridine monophosphate (an active metabolite) and fluorouracil; 6080% excreted by the lungs as respiratory CO. Small amounts of fluorouracil (<1015%) excreted unchanged by the kidneys.
Half-life: Fluorouracil: 20 hr.
(effects on blood counts)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
Intra-arterial | 19 days | 921 days | 30 days |
Noted as effects due to conversion to fluorouracil.
NDC Code*