• Moderate to severe vasomotor symptoms due to menopause.

Contraindicated in:

• Cirrhosis
• Severe renal impairment or end-stage renal disease
• Concurrent use with CYP1A2 inhibitors.

Use Cautiously in:

• None.

Derm: hot flush.

GI: ↑ liver enzymes, abdominal pain, diarrhea.

MS: back pain.

Neuro: insomnia.

Drug-Drug:

• CYP1A2 inhibitors, including fluvoxamine, mexiletine, and cimetidine ↑ levels and risk of toxicity; concurrent use contraindicated.

• Tablets: 45 mg;

• PO (Adults): 45 mg once daily.

Veozah

• Acts as a neurokinin 3 receptor antagonist that blocks neurokinin B binding on the kisspeptin/neurokinin B/dynorphin neuron to regulate neuronal activity in the thermoregulatory center.

• Reduction in frequency and severity of vasomotor symptoms due to menopause.

Therapeutic Classification:

Pharmacologic Classification: neurokinin 3 receptor antagonists

Absorption: Extent of absorption unknown.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP1A2 isonezyme, with some metabolism by the CYP2C9 and CYP2C19 isoenzymes. Primarily excreted in the urine (77%; 1% as unchanged drug), with 15% excreted in the feces (<1% as unchanged drug).

Half-life: 9.6 hr.

(plasma concentrations)

• Instruct patient to take fezolinetant as directed. Take missed doses as soon as remembered, unless there is <12 hr before next dose is due. Return to regular schedule next day. Advise patient to read Patient Information before starting and with each Rx refill in case of changes.
• Advise patient to notify health care professional promptly if signs and symptoms of liver problems (nausea, vomiting, yellowing of the eyes or skin, pain in the right upper abdomen) occur.
• Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
• Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

FEZ-oh-LIN-e-tant