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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: headache, dizziness.

EENT: cataracts, dysphonia, glaucoma, hoarseness, oropharyngeal fungal infections, nasal stuffiness, rhinorrhea, sinusitis.

Endo: adrenal suppression (high-dose, long-term therapy only), bone mineral density, growth (in children), Cushing's syndrome.

GI: diarrhea.

MS: muscle pain.

Resp: bronchospasm, cough, upper respiratory tract infection, wheezing.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, LARYNGEAL EDEMA, BRONCHOSPASM, AND URTICARIA), CHURG-STRAUSS SYNDROME, fever.

Interactions

Drug-Drug:

Availability

Route/Dosage

Aerosol for Oral Inhalation

Powder for Oral Inhalation

US Brand Names

Armonair Respiclick, Arnuity Ellipta, Flovent Diskus, Flovent HFA

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: corticosteroids

Pharmacologic Classification: corticosteroids

Pharmacokinetics

Absorption: <1% (aerosol), 8–14% (powder). Action is primarily local after inhalation.

Distribution: 10–25% of inhaled corticosteroids is deposited in the airways if a spacer device is not used. With the use of a spacer, a greater percentage may reach the respiratory tract. Crosses the placenta and enters breast milk in small amounts.

Protein Binding: 91–99%.

Metabolism/Excretion: Metabolized by the liver primarily by the CYP3A4 isoenzyme after absorption from lungs; <5% excreted in urine; remainder excreted in feces.

Half-life: 7.8 hr (propionate); 24 hr (furoate).

Time/Action Profile

(improvement in symptoms)

ROUTEONSETPEAKDURATION
Inhalationwithin 24 hr1–4 wkseveral days after discontinuation

†Improvement in pulmonary function; decreased airway responsiveness may take longer.

Patient/Family Teaching

Pronunciation

floo-TI-ka-sone audio

Pill Image

fluticasone_propionate_195_9146.jpg

Code

NDC Code*