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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CNS: SEIZURES, anxiety, dizziness, headache, rigors.

CV: CARDIOVASCULAR COLLAPSE, arrhythmias, bradycardia, chest pain, hypertension, hypotension, tachycardia.

GI: nausea, vomiting.

GU: urinary retention.

Derm: pruritus.

F and E: hypokalemia, metabolic acidosis.

Hemat: anemia.

Neuro: circumoral tingling/numbness, paresthesia.

Resp: dyspnea.

MS: chondrolysis.

Misc: allergic reactions, fever.

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Surgical Anesthesia

Labor Pain

Postoperative Pain

US Brand Names ⬆ ⬇

Naropin

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: epidural local anesthetics, anesthetics (topical/local)

Pharmacokinetics ⬆ ⬇

Absorption: Systemic absorption follows epidural administration, but amount absorbed depends on dose.

Distribution: If systemic absorption occurs, this agent is widely distributed and crosses the placenta.

Metabolism/Excretion: Small amounts that may reach systemic circulation are mostly metabolized by the liver; <1% excreted unchanged in the urine.

Half-life: 4.2 hr (after epidural use).

Time/Action Profile ⬆ ⬇

(analgesia)

ROUTEONSETPEAKDURATION
Epidural10–30 minunknown2–8 hr†

†Duration of anesthetic block.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

ROE-pi-vi-kane audio

Code ⬆

NDC Code*