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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision, dry eyes.

GI: dry mouth, constipation, dyspepsia.

Neuro: dizziness, headache, sedation.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA).

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Immediate-Release Tablets

Hepatic Impairment

Extended-Release Capsules

Hepatic Impairment

US Brand Names ⬆ ⬇

Detrol, Detrol LA

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: anticholinergics

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (77%) following oral administration.

Distribution: Extensively distributed to tissues.

Protein Binding: 96.3%.

Metabolism/Excretion: Extensively metabolized by the liver, via the CYP2D6 isoenzyme; (the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly ↑ tolterodine concentrations and an ↑ risk of adverse effects); one metabolite (5-hydroxymethyltolterodine) is active; other metabolites are excreted in urine.

Half-life: Tolterodine: 1.9–3.7 hr; 5-hydroxymethyltolterodine: 2.9–3.1 hr.

Time/Action Profile ⬆ ⬇

(effects on bladder function)

ROUTEONSETPEAKDURATION
POunknownunknown12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

tol-TER-oh-deen audio

Pill Image

tolterodine_tartrate_195_8732.jpg

Code ⬆

NDC Code*