Contraindicated in:
Use Cautiously in:
Derm: alopecia, rash.
EENT: ototoxicity.
F and E: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia.
GI: abdominal pain, nausea, vomiting, constipation, diarrhea, hepatitis, stomatitis.
GU: gonadal suppression, nephrotoxicity.
Hemat: ANEMIA, LEUKOPENIA, THROMBOCYTOPENIA.
Metab: hyperuricemia.
Neuro: peripheral neuropathy, weakness.
Drug-Drug:
Renal Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: Well distributed to tissues.
Protein Binding: Platinum is irreversibly bound to plasma proteins.
Metabolism/Excretion: Excreted mostly by the kidneys.
Half-life: Carboplatin: 2.6–5.9 hr (↑ in renal impairment); platinum: 5 days.
NDC Code*
