Contraindicated in:
Use Cautiously in:
CV: HF, hypertension, peripheral edema.
Derm: pruritus, rash.
EENT: ↑ lacrimation, blurred vision, conjunctivitis, dry eyes.
F and E: hypokalemia.
GI: ↑ liver enzymes, constipation, nausea, altered taste, diarrhea, dry mouth, dyspepsia, HEPATOTOXICITY, stomatitis, vomiting.
GU: ↓ fertility.
Hemat: anemia, HEMORRHAGE, neutropenia, THROMBOCYTOPENIA.
MS: musculoskeletal pain, arthralgia, myalgia.
Neuro: fatigue, headache, peripheral neuropathy, dizziness, insomnia, weakness.
Resp: cough, INTERSTITIAL LUNG DISEASE.
Misc: chills, fever, HYPERSENSITIVITY REACTIONS, infusion-related reactions.
Drug-Drug:
Metastatic Breast Cancer
Early Breast Cancer
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: DM1 is metabolized by CYP3A4/5.
Half-life: 4 days.