Contraindicated in:
Use Cautiously in:
CV: chest pain, HF, atrial fibrillation, edema, hypertension, hypotension, tachycardia, THROMBOEMBOLIC EVENTS.
Derm: photosensitivity.
F and E: dehydration.
GI: abdominal pain, constipation, esophageal stricture, nausea, vomiting, GI BLEEDING, GI/ESOPHAGEAL PERFORATION, anorexia, diarrhea, dyspepsia, eructation, esophageal tumor bleeding.
GU: moniliasis, urinary tract infection.
Hemat: anemia.
Metab: ↓ weight.
Neuro: insomnia, anxiety, confusion, weakness.
Resp: mucositis reaction, dyspnea, pharyngitis, pleural effusion, pneumonia, cough, PULMONARY BLEEDING, RESPIRATORY DISTRESS, tracheoesophageal fistula.
Drug-Drug:
Absorption: IV administration results in complete bioavailability.
Distribution: Retained for a longer period by tumors, skin, and reticuloendothelial tissue.
Protein Binding: 90%.
Metabolism/Excretion: Unknown.
Half-life: 410 hr (first dose); 725 hr (2nd dose).
NDC Code*