Contraindicated in:
Use Cautiously in:
CV: hypertension, peripheral edema, CARDIOMYOPATHY, DEEP VENOUS THROMBOSIS (DVT).
Derm: rash.
EENT: retinopathy, visual impairment, macular edema, retinal detachment, retinal vein occlusion (RVO), uveitis.
F and E: hyponatremia.
GI: ↑ liver enzymes, abdominal pain, constipation, diarrhea, nausea, vomiting, colitis, HEPATOTOXICITY.
GU: ↑ serum creatinine.
Hemat: anemia, hemorrhage, leukopenia, lymphopenia, neutropenia.
MS: ↑ creatine kinase, RHABDOMYOLYSIS.
Resp: INTERSTITIAL LUNG DISEASE (ILD), PULMONARY EMBOLISM (PE).
Misc: fever.
Hepatic Impairment
Absorption: At least 50% absorbed following oral administration.
Distribution: Extensively distributed to tissues.
Protein Binding: 97%.
Metabolism/Excretion: Mostly metabolized by the liver via glucuronidation. 62% excreted in feces (32% as unchanged drug); 31% excreted in urine (6.5% as unchanged drug).
Half-life: 3.5 hr.
NDC Code*