Contraindicated in:
Use Cautiously in:
CV: atrial fibrillation.
GI: ↑ liver enzymes, abdominal pain.
GU: ↑ blood urea nitrogen, ↑ serum creatinine, benign prostatic hyperplasia.
Hemat: anemia.
Metab: hyperuricemia, gout.
MS: ↑ creatine kinase, back pain, muscle spasm, tendon rupture/injury.
Resp: upper respiratory tract infection.
Drug-Drug:
Absorption: Unknown.
Distribution: Some distribution to extravascular tissues.
Metabolism/Excretion: Metabolized in liver to active metabolite (ESP15228); both parent drug and ESP15228 are also metabolized via glucuronidation to inactive metabolites. 70% excreted in urine and 30% excreted in feces primarily as metabolites (<5% excreted as unchanged drug in urine and feces).
Half-life: 21 hr.