• Prevention and treatment of influenza A infection in high-risk adults.
• Prevention of influenza A infection in high-risk children.

Unlabeled Use:

• Treatment of influenza A infection in children.

Contraindicated in:

• Hypersensitivity to rimantadine or amantadine
• Lactation: Lactation.

Use Cautiously in:

• History of seizures
• Severe hepatic or renal impairment (dose ↓ recommended if CCr <30 mL/min)
• Geri: May be at ↑ risk for GI effects
• OB: Safety not established.

CNS: SEIZURES, agitation, dizziness, fatigue, headache, impaired concentration, insomnia, mental depression.

EENT: tinnitus.

Resp: dyspnea.

GI: abdominal pain, anorexia, diarrhea, dry mouth, dyspepsia, nausea, vomiting.

Derm: rash.

Drug-Drug:

• Aspirin and acetaminophen may ↓ levels.
• May interfere with efficacy of intranasal influenza virus vaccine, do not administer within 48 hr before or 2 wk after.

(Generic available)

• Tablets: 100 mg;

• PO (Adults): Prevention-100 mg twice daily (duration range = 11 days-6 wk). Treatment-100 mg twice daily for 7 days.
• PO (Geriatric Patients , Patients with Severe Hepatic or Severe Renal Impairment [CCr <30 mL/min]): Prevention-100 mg daily.
• PO (Children 10–16 yr): Prevention-100 mg twice daily (duration range = 5–6 wk).
• PO (Children 1–9 yr): Prevention-5 mg/kg/day as a single dose (not to exceed 150 mg/day) (duration range = 5–6 wk).

Flumadine

• Diminishes replication of influenza A virus by inhibiting uncoating of the virus.

• When given prophylactically, prevents infection with influenza A virus. When administered within 48 hr of onset of infections, decreases the duration of fever and other associated symptoms.

Therapeutic Classification: antivirals

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver; <25% excreted unchanged in urine.

Half-life: 25 hr (range 13–65 hr).

(blood levels)

• Advise patient to take medication as directed at evenly spaced times for full course of therapy, even if feeling well. Take missed doses as soon as possible unless almost time for next dose; do not double up on missed doses.
• May cause dizziness. Advise patient to avoid driving or other activities that require alertness until response to the drug is known.
• Advise patient to consult health care professional about receiving a flu vaccination.
• Inform patient that frequent mouth rinses, good oral hygiene, and sugarless gum or candy may decrease dry mouth.
• Advise patient to consult health care professional before taking OTC medications or herbal products, especially aspirin or acetaminophen, or drinking alcoholic beverages.
• Instruct patient and family to notify health care professional if influenza symptoms occur.

ri-MAN-ti-deen

NDC Code^*

• 0115- Amneal Pharmaceuticals of New York LLC
  • 0115-1911- Rimantadine Hydrochloride
    • 0115-1911-01- 100 TABLET, FILM COATED in 1 BOTTLE (0115-1911-01)

• 0115- Amneal Pharmaceuticals of New York LLC
  • 0115-1911- Rimantadine Hydrochloride
    • 0115-1911-02- 500 TABLET, FILM COATED in 1 BOTTLE (0115-1911-02)

• 63629- Bryant Ranch Prepack
  • 63629-3552- Rimantadine Hydrochloride
    • 63629-3552-1- 30 TABLET, FILM COATED in 1 BOTTLE (63629-3552-1)

• 63629- Bryant Ranch Prepack
  • 63629-3552- Rimantadine Hydrochloride
    • 63629-3552-2- 10 TABLET, FILM COATED in 1 BOTTLE (63629-3552-2)