Contraindicated in:
Use Cautiously in:
CV: hypotension, volume depletion.
Endo: hypoglycemia (↑ with other medications).
F and E: hyperphosphatemia, KETOACIDOSIS.
GU: ↑ urination, acute kidney injury, genital mycotic infections, NECROTIZING FASCIITIS OF PERINEUM (FOURNIER'S GANGRENE), renal impairment, urinary tract infection(including pyelonephritis), UROSEPSIS.
Metab: hyperlipidemia.
Drug-Drug:
(Generic available)
Type 2 Diabetes
Type 2 Diabetes in Patients with Established Cardiovascular Disease
Heart Failure
Therapeutic Classification: antidiabetics
Pharmacologic Classification: sodium-glucose co-transporter 2 (SGLT2) inhibitors
Absorption: Well absorbed following oral administration.
Distribution: Enters red blood cells, remainder of distribution unknown.
Metabolism/Excretion: Minimally metabolized; excreted in feces (41.2% mostly as unchanged drug) and urine (54.4% half as unchanged drug, half as metabolites).
Half-life: 12.4 hr.
NDC Code*