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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Endo: gynecomastia

GI: constipation, diarrhea, drug-induced hepatitis, nausea

GU: ↓sperm count, erectile dysfunction

Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, anemia, neutropenia, thrombocytopenia

Neuro: confusion, dizziness, drowsiness, hallucinations, headache

Misc: hypersensitivity reactions

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Axid, Axid AR

Action ⬆ ⬇

  • Inhibits the action of histamine at the H2-receptor site located primarily in gastric parietal cells, resulting in inhibition of gastric acid secretion.
Therapeutic effects:
  • Healing and prevention of ulcers.
  • Decreased symptoms of GERD.
  • Decreased secretion of gastric acid.

Classifications ⬆ ⬇

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: histamine h2 antagonists

Pharmacokinetics ⬆ ⬇

Absorption: 70–95% absorbed after oral administration.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Undergoes some hepatic metabolism; at least 1 metabolite has histamine blocking activity. 60% excreted unchanged by the kidneys.

Half-Life: 1.6 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknown8–12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

ni-ZA-ti-deen

Code ⬆

NDC Code