Contraindicated in:
Use Cautiously in:
CV: hypotension, ARRHYTHMIAS, ECG changes.
Derm: photosensitivity.
EENT: blurred vision, dry eyes.
Endo: gynecomastia.
GI: constipation, dry mouth, nausea, paralytic ileus, unpleasant taste.
GU: urinary retention.
Hemat: blood dyscrasias.
Metab: weight gain.
Neuro: drowsiness, fatigue, lethargy, agitation, confusion, extrapyramidal reactions, hallucinations, headache, insomnia, SUICIDAL THOUGHTS.
Drug-Drug:
Drug-Natural Products:
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: 92%.
Metabolism/Excretion: Mostly metabolized by the liver by the CYP2D6 isoenzyme;the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly ↑ nortriptyline concentrations and an ↑ risk of adverse effects.
Half-life: 18–28 hr.
NDC Code*