amiloride

Contraindicated in:

Hypersensitivity;
Hyperkalemia;
Concurrent use of potassium supplements or other potassium-sparing agents.

Use Cautiously in:

Hepatic dysfunction;
Patients with diabetes mellitus (↑ risk of hyperkalemia);
Renal insufficiency;
OB: Safety not established.

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias

F and E: hyperkalemia, hyponatremia

GI: constipation, nausea, vomiting

MS: muscle cramps

Neuro: dizziness, headache

Misc: allergic reactions

Interactions ⬆ ⬇

Drug-drug:

↑risk of hypotension with acute ingestion of alcohol, other antihypertensive agents, or nitrates.
Use with ACE inhibitors,angiotensin II receptor antagonistsindomethacin, potassium supplements, or cyclosporine↑ risk of hyperkalemia.
↓lithium excretion.
Effectiveness may be ↓ by NSAIDs.

Availability ⬆ ⬇

(Generic available)

Tablets: 5 mg

Route/Dosage ⬆ ⬇

PO (Adults ): 5–10 mg/day (up to 20 mg).

Action ⬆ ⬇

Inhibition of sodium resorption in the kidney, saving potassium and hydrogen ions.

Therapeutic effects:

Weak diuretic and antihypertensive response when compared with other diuretics.
Conservation of potassium.

Classifications ⬆ ⬇

Therapeutic Classification: diuretics, potassium sparing diuretics

Pharmacokinetics ⬆ ⬇

Absorption: 30–90% absorbed.

Distribution: Widely distributed.

Metabolism/Excretion: 50% eliminated unchanged in urine, 40% excreted in the feces.

Half-Life: 6–9 hr.

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

(diuretic effect)

ROUTE	ONSET	PEAK	DURATION
PO	2 hr‡	6–10 hr‡	24 hr‡

‡Single dose.

Patient/Family Teaching ⬆ ⬇

Emphasize the importance of continuing to take this medication at the same time each day, even if feeling well. Take missed doses as soon as remembered unless almost time for next dose. Do not double doses.
- Caution patient to avoid salt substitutes and foods that contain high levels of potassium or sodium unless prescribed by health care professional.
- May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
- Advise patient to consult with health care professional before taking any OTC decongestants, cough or cold preparations, or appetite suppressants concurrently with this medication.
- Instruct patient to notify health care professional of medication regimen before treatment or surgery.
- Advise patient to notify health care professional if muscle weakness or cramps; fatigue; or severe nausea, vomiting, or diarrhea occurs.
- Emphasize the need for follow-up exams to monitor progress.
Hypertension: Reinforce need to continue additional therapies for hypertension (weight loss, restricted sodium intake, stress reduction, moderation of alcohol intake, regular exercise, and cessation of smoking). Medication helps control but does not cure hypertension.
- Teach patient and family the correct technique for checking BP weekly.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

49884- Par Pharmaceutical, Inc.
- 49884-117- Amiloride Hydrochloride
  - 49884-117-01- 100 TABLET in 1 BOTTLE (49884-117-01)

49884- Par Pharmaceutical, Inc.
- 49884-117- Amiloride Hydrochloride
  - 49884-117-10- 1000 TABLET in 1 BOTTLE (49884-117-10)

50268- AvPAK
- 50268-071- Amiloride Hydrochloride
  - 50268-071-15- 50 BLISTER PACK in 1 BOX, UNIT-DOSE (50268-071-15) > 1 TABLET in 1 BLISTER PACK (50268-071-11)

60429- Golden State Medical Supply, Inc.
- 60429-275- Amiloride Hydrochloride
  - 60429-275-01- 100 TABLET in 1 BOTTLE (60429-275-01)

60429- Golden State Medical Supply, Inc.
- 60429-275- Amiloride Hydrochloride
  - 60429-275-90- 90 TABLET in 1 BOTTLE (60429-275-90)

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Indications ⬇

Contraind./Precautions ⬆ ⬇