trospium

Contraindicated in:

Hypersensitivity;
Gastric or urinary retention, uncontrolled angle-closure glaucoma or risk for these conditions.

Use Cautiously in:

Bladder outflow obstruction;
Gastrointestinal obstructive disorders (ulcerative colitis, intestinal atony, myasthenia gravis);
Controlled angle-closure glaucoma (use only if necessary and with careful monitoring);
CCr <30 mL/min (dose ↓ recommended);
Moderate to severe hepatic impairment;
OB: Use only if benefit justifies risks to fetus/newborn;
Pedi: Safety not established;
Geri: May have↑ sensitivity to anticholinergic effects; ↓ dose may be required.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision

GI: constipation, dry mouth, dyspepsia

GU: urinary retention, urinary tract infection

Neuro: headache, confusion, dizziness, drowsiness, fatigue, hallucinations

Misc: ANGIOEDEMA, fever, heat stroke

Interactions ⬆ ⬇

Drug-drug:

May interact with other drugs that compete for tubular secretion.
Metformin may ↓ levels.
↑risk of anticholinergic effects with other drugs having anticholinergic properties.

Availability ⬆ ⬇

(Generic available)

Tablets: 20 mg
Extended release tablets: 60 mg

Route/Dosage ⬆ ⬇

PO (Adults ): 20 mg twice daily or 60 mg once daily (XR dose form).
PO (Adults ≥75 yr): Based on tolerability, dose may be ↓ to 20 mg once daily.

Renal Impairment

PO (Adults ): CCr <30 mL/min: 20 mg once daily at bedtime.

US Brand Names ⬆ ⬇

Sanctura, Sanctura XR

Action ⬆ ⬇

Antagonizes the effect of acetylcholine at muscarinic receptors in the bladder; this parasympatholytic action reduces bladder smooth muscle tone.

Therapeutic effects:

Increased bladder capacity and decreased symptoms of overactive bladder.

Classifications ⬆ ⬇

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: antimuscarinics

Pharmacokinetics ⬆ ⬇

Absorption: Less than 10% absorbed following oral administration; food significantly ↓ absorption.

Distribution: Mostly distributed to plasma.

Metabolism/Excretion: Of the 10% absorbed, 40% is metabolized. Unabsorbed drug is mainly excreted in feces. Of absorbed drug, 60% is eliminated in urine as unchanged drug via active tubular secretion.

Half-Life: 20 hr.

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

(anticholinergic effects)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	5–6 hr	24 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take as directed. If a dose is skipped, take next dose 1 hr prior to next meal.
May cause drowsiness, dizziness, and blurred vision. Caution patient to avoid driving and other activities requiring alertness until response to medication is known. Advise patient to avoid alcohol; may increase drowsiness.
Advise patient to notify health care professional immediately of signs and symptoms of angioedema (edema of the tongue or laryngopharynx, difficulty breathing) occur.
Caution patient that heat prostration (fever and heat stroke due to decreased sweating) may occur when trospium is taken in a hot environment.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
Advise female patient to notify health care professional if pregnancy is planned or suspected, or if breast feeding.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0574- Paddock Laboratories, LLC
- 0574-0118- Trospium Chloride ER
  - 0574-0118-30- 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE (0574-0118-30)

0574- Paddock Laboratories, LLC
- 0574-0145- TROSPIUM CHLORIDE
  - 0574-0145-60- 60 TABLET, FILM COATED in 1 BOTTLE (0574-0145-60)

0591- Actavis Pharma, Inc.
- 0591-3636- Trospium Chloride
  - 0591-3636-05- 500 CAPSULE, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (0591-3636-05)

0591- Actavis Pharma, Inc.
- 0591-3636- Trospium Chloride
  - 0591-3636-30- 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (0591-3636-30)

0591- Actavis Pharma, Inc.
- 0591-3636- Trospium Chloride
  - 0591-3636-60- 60 CAPSULE, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (0591-3636-60)

23155- Heritage Pharmaceuticals Inc.
- 23155-530- Trospium Chloride
  - 23155-530-02- 200 TABLET, FILM COATED in 1 BOTTLE (23155-530-02)

23155- Heritage Pharmaceuticals Inc.
- 23155-530- Trospium Chloride
  - 23155-530-05- 500 TABLET, FILM COATED in 1 BOTTLE (23155-530-05)

23155- Heritage Pharmaceuticals Inc.
- 23155-530- Trospium Chloride
  - 23155-530-06- 60 TABLET, FILM COATED in 1 BOTTLE (23155-530-06)

42291- AvKARE, Inc.
- 42291-846- TROSPIUM CHLORIDE
  - 42291-846-60- 60 TABLET in 1 BOTTLE (42291-846-60)

60429- Golden State Medical Supply, Inc.
- 60429-098- Trospium Chloride
  - 60429-098-30- 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (60429-098-30)

60505- Apotex Corp.
- 60505-3454- TROSPIUM CHLORIDE
  - 60505-3454-5- 500 TABLET in 1 BOTTLE (60505-3454-5)

60505- Apotex Corp.
- 60505-3454- TROSPIUM CHLORIDE
  - 60505-3454-6- 60 TABLET in 1 BOTTLE (60505-3454-6)

60505- Apotex Corp.
- 60505-3454- TROSPIUM CHLORIDE
  - 60505-3454-8- 1000 TABLET in 1 BOTTLE (60505-3454-8)

68001- BluePoint Laboratories
- 68001-228- Trospium Chloride
  - 68001-228-04- 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (68001-228-04)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-461- Trospium Chloride
  - 68462-461-05- 500 TABLET, FILM COATED in 1 BOTTLE (68462-461-05)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-461- Trospium Chloride
  - 68462-461-30- 30 TABLET, FILM COATED in 1 BOTTLE (68462-461-30)

68462- Glenmark Pharmaceuticals Inc., USA
- 68462-461- Trospium Chloride
  - 68462-461-60- 60 TABLET, FILM COATED in 1 BOTTLE (68462-461-60)

69097- CIPLA USA INC.,
- 69097-912- Trospium Chloride
  - 69097-912-02- 30 TABLET, FILM COATED in 1 BOTTLE (69097-912-02)

69097- CIPLA USA INC.,
- 69097-912- Trospium Chloride
  - 69097-912-03- 60 TABLET, FILM COATED in 1 BOTTLE (69097-912-03)

69097- CIPLA USA INC.,
- 69097-912- Trospium Chloride
  - 69097-912-15- 1000 TABLET, FILM COATED in 1 BOTTLE (69097-912-15)

76282- Exelan Pharmaceuticals Inc.
- 76282-336- Trospium Chloride
  - 76282-336-60- 60 TABLET, FILM COATED in 1 BOTTLE (76282-336-60)

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Indications ⬇

Contraind./Precautions ⬆ ⬇