CV: QT interval prolongation, AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES.
Derm: photosensitivity, rash, STEVENS-JOHNSON SYNDROME.
Endo: hyperglycemia, hypoglycemia.
GI: diarrhea, nausea, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, vomiting.
GU: vaginitis.
MS: arthralgia, myalgia, tendinitis, tendon rupture.
Neuro: agitation, anxiety, confusion, depression, dizziness , ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS, toxic psychosis, tremor.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS).
Acute Bacterial Exacerbations of Chronic Bronchitis
- PO (Adults): 400 mg every 12 hr for 10 days.
Community-Acquired Pneumonia
- PO (Adults): 400 mg every 12 hr for 10 days.
Uncomplicated Skin/Skin Structure Infections
- PO (Adults): 400 mg every 12 hr for 10 days.
Uncomplicated Urethral and Cervical Gonorrhea
- PO (Adults): 400 mg single dose.
Nongonococcal Urethritis/Cervicitis
- PO (Adults): 300 mg every 12 hr for 7 days.
Mixed Infection of the Urethra and Cervix
- PO (Adults): 300 mg every 12 hr for 7 days.
Acute Pelvic Inflammatory Disease
- PO (Adults): 400 mg every 12 hr for 10–14 days.
Urinary Tract Infections
- PO (Adults): Uncomplicated cystitis due to E. coli or Klebsiella pneumoniae: 200 mg every 12 hr for 3 days; Uncomplicated cystitis due to Citrobacter diversus, Enterobacter aerogenes, Proteus mirabilis, or Pseudomonas aeruginosa: 200 mg every 12 hr for 7 days; Complicated urinary tract infection: 200 mg every 12 hr for 10 days.
Prostatitis
- PO (Adults): 300 mg every 12 hr for 6 wk.
Renal Impairment
- PO (Adults): CCr 20–50 mL/min: 100% of the usual dose every 24 hr; CCr <20 mL/min: 50% of the usual dose every 24 hr.
- Otic (Adults and Children
6 mo): Otitis externa 6 mo to 13 yr: : 5 drops instilled into affected ear once daily for 7 days; Otitis externa 13 yr: 10 drops instilled into affected ear once daily for 7 days. Acute otitis media in patients 1–12 yr old with tympanostomy tubes: 5 drops instilled into the affected ear twice daily for 10 days. Chronic suppurative otitis media with perforated tympanic membranes in patients 12 yr: 10 drops instilled into the affected ear twice daily for 14 days.
Therapeutic Classification: anti-infectives
Pharmacologic Classification: Fluoroquinolones
Absorption: Well absorbed (98%) following oral administration.
Distribution: Widely distributed. High tissue and urinary levels are achieved. Appears to cross the placenta; enters breast milk.
Metabolism/Excretion: 70–80% excreted unchanged by the kidneys.
Half-life: 5–7 hr.
50 mL/min)