- IM IV (Adults ): Most infections: 1 g every 6–8 hr. Severe infections: 1 g every 4 hr or 2 g every 6–8 hr. Life-threatening infections: 2 g every 4 hr or 3 g every 6 hr.Perioperative prophylaxis: 2 g 30–60 min before initial incision, then 2 g every 6 hr for up to 24 hr.
- IM IV (Children and Infants >1 mo): Mild to moderate infections: 80 mg/kg/day divided every 6 hr (max = 4 g/day).Severe infections: 160 mg/kg/day divided every 6 hr (max = 12 g/day. Perioperative prophylaxis: 30–40 mg/kg within 60 min of incision, then 30–40 mg/kg every 6 hr for up to 24 hr.
- IM IV (Neonates ): 90–100 mg/kg/day divided every 8 hr.
Renal Impairment
- IM IV (Adults ): CCr 30–50 mL/min: Administer every 8–12 hr; CCr 10–29 mL/min: Administer every 12–24 hr; CCr <10 mL/min: Administer every 24–48 hr.
