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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria

GI: diarrhea, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, nausea, vomiting

GU: vaginal moniliasis

Hemat: bleeding, blood dyscrasias, hemolytic anemia

Neuro: headache, SEIZURES (VERY HIGH DOSES)

Misc: ANAPHYLAXIS ALLERGIC REACTIONS INCLUDING , superinfection

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Vantin

Action ⬆ ⬇

  • Binds to the bacterial cell wall membrane, causing cell death.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: third generation cephalosporins

Pharmacokinetics ⬆ ⬇

Absorption: Cefpodoxime proxetil is a prodrug that is converted to cefpodoxim (the active component) in GI tract during absorption; 50% absorbed after oral administration; absorption of tablets ↑ with food.

Distribution: Widely distributed. Crosses the placenta; enters breast milk.

Metabolism/Excretion: 29–33% excreted unchanged in urine.

Half-Life: 2–3 hr (↑ in renal impairment).

Canadian Brand Names ⬆ ⬇

Simplicef

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTEONSETPEAKDURATION
POunknown2–3 hr12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

sef-poe-DOX-eem

Code ⬆

NDC Code