section name header

Indications ⬇

BEERS REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, HF, hypertension, MI

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS

EENT: blurred vision, tinnitus

F and E: hyperkalemia

GI: discomfort, dyspepsia, nausea, vomiting, anorexia, constipation, diarrhea, flatulence, GI BLEEDING, HEPATOTOXICITY

GU: renal failure

Hemat: blood dyscrasias, prolonged bleeding time

Neuro: drowsiness, headache, dizziness, STROKE

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Feldene

Action ⬆ ⬇

  • Inhibits prostaglandin synthesis.
Therapeutic effects:
  • Suppression of pain and inflammation.

Classifications ⬆ ⬇

Therapeutic Classification: antirheumatics, nonopioid analgesics

Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract.

Distribution: Unknown. Enters breast milk in small amounts.

Metabolism/Excretion: Mostly metabolized by the liver primarily by the CYP2C9 isoenzyme. Patients who are poor CYP2C9 metabolizers may have reduced metabolism of piroxicam, which may lead to ↑ toxicity. Minimal amounts excreted unchanged by the kidneys.

Half-Life: 50 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
PO (analgesic effect)1 hrunknown48–72 hr
PO (anti-inflammatory effect)7–12 days2–3 wk‡unknown

‡May take up to 12 wk.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

peer-OX-i-kam

Code ⬆

NDC Code