• PO (Adults and Children >50 kg): Hyperuricemia: 250 mg twice daily for 1 wk; ↑ to 500 mg twice daily, then may ↑ by 500 mg/day every 4 wk (not to exceed 3 g/day).Augmentation of penicillins/cephalosporins: 500 mg 4 times daily. Single-dose therapy of gonorrhea: 1 g with amoxicillin or penicillin.
• PO (Children 2–14 yr and 50 kg): 25 mg/kg (700 mg/m²) initially; then 10 mg/kg (300 mg/m²) 4 times daily.

• Inhibits renal tubular reabsorption of uric acid, thus promoting its renal excretion.

• Reduction of serum uric acid levels.
• Prolonged serum levels of penicillins and other related antibiotics.

Therapeutic Classification: antigout agents, uricosurics

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Protein Binding: 75–95%.

Metabolism/Excretion: Mostly metabolized by the liver; 10% excreted unchanged in the urine.

Half-life: 4–17 hr.

(effects on serum uric acid levels)

• Instruct patient to take medication exactly as directed and not to discontinue without consulting health care professional. Irregular dosage schedules may cause elevation of uric acid levels and precipitate an acute gout attack.
• Explain purpose of the medication to patients taking probenecid with penicillin.
• Advise patient to follow recommendations of health care professional regarding weight loss, diet, and alcohol consumption.
• Caution patient not to take aspirin or other salicylates, because they decrease the effects of probenecid.
• Instruct patient to report nausea, vomiting, loss of appetite, abdominal pain, unusual bleeding or bruising, sore throat, fatigue, malaise, or yellowing of the skin or eyes promptly.
• Rep: Advise females of reproductive potential to notify health care professional if breastfeeding is planned.

proe-BEN-e-sid

NDC Code^*

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