section name header

Indications ⬇

REMS

POTransdermal

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, HF, hypotension

Derm: allergic dermatitis

GI: anorexia, diarrhea, nausea, vomiting, ↓weight, abdominal pain, dyspepsia, flatulence

Local: application reactions (for transdermal patch only)

Neuro: weakness, dizziness, drowsiness, headache, tremor

Misc: fever

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hepatic Impairment

US Brand Names ⬆ ⬇

Exelon

Action ⬆ ⬇

  • Enhances cholinergic function by reversible inhibition of cholinesterase.
Therapeutic effects:
  • Decreased dementia (temporary) associated with Alzheimer's disease and Parkinson's disease.
  • Enhanced cognitive ability.

Classifications ⬆ ⬇

Therapeutic Classification: anti-Alzheimers's agents

Pharmacologic Classification: cholinergics (cholinesterase inhibitors)

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration. Transdermal patch is slowly absorbed over 8 hr.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Rapidly and extensively metabolized by the liver; metabolites are excreted by the kidneys.

Half-Life: PO: 1.5 hr; Transdermal: 24 hr.

Time/Action Profile ⬆ ⬇

(improvement in dementia)

ROUTEONSETPEAKDURATION
POwithin 2 wkup to 12 wkunknown
Transdermalunknownunknownunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

rye-va-STIG-meen

Code ⬆

NDC Code