alfuzosin

REMS

Management of symptomatic benign prostatic hyperplasia (BPH).

Contraindicated in:

Hypersensitivity;
Moderate to severe hepatic impairment;
Concurrent use of strong CYP3A4 inhibitors;
Concurrent use of other alpha-adrenergic blocking agents;
Severe renal impairment.

Use Cautiously in:

Congenital or acquired QTc prolongation or concurrent use of other drugs known to prolong QTc;
Mild hepatic impairment;
Symptomatic hypotension;
Concurrent use of antihypertensive agents, phosphodiesterase type 5 inhibitors, or nitrates (↑ risk of postural hypotension);
Previous hypotensive episode with other medications;
Geri: Consider age-related changes in body mass and cardiac, renal, and hepatic function when prescribing in older adults.

CV: postural hypotension

Derm: TOXIC EPIDERMAL NECROLYSIS

EENT: intraoperative floppy iris syndrome

GI: abdominal pain, constipation, dyspepsia, nausea

GU: erectile dysfunction, priapism

Hemat: thrombocytopenia

Neuro: dizziness, fatigue, headache

Resp: bronchitis, pharyngitis, sinusitis

Drug-drug:

Strong CYP3A4 inhibitors, including ketoconazole, itraconazole, and ritonavir, may significantly ↑ levels and risk of toxicity; concurrent use contraindicated.
Cimetidine, atenolol, and diltiazem may ↑ levels and risk of toxicity.
May ↑ levels and risk of toxicity of atenolol and diltiazem; monitor BP and heart rate.
↑risk of hypotension with antihypertensives, nitrates, phosphodiesterase type 5 inhibitors (including sildenafil, tadalafil, and vardenafil) and acute ingestion of alcohol.

(Generic available)

Extended-release tablets: 10 mg

PO (Adults ): 10 mg once daily.

Uroxatral

Selectively blocks alpha₁-adrenergic receptors in the lower urinary tract to relax smooth muscle in the bladder neck and prostate.

Therapeutic effects:

Increased urine flow and decreased symptoms of BPH.

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: peripherally acting antiadrenergics

Absorption: 49% absorbed following oral administration; food enhances absorption.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP3A4 isoenzyme system; 11% excreted unchanged in urine.

Half-Life: 10 hr.

Xatral

ROUTE	ONSET	PEAK	DURATION
PO-ER	within hr	8 hr	24 hr

Instruct patient to take medication with the same meal each day. Take missed doses as soon as remembered. If not remembered until next day, omit; do not double doses.
- May cause dizziness or drowsiness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
- Caution patient to avoid sudden changes in position to decrease orthostatic hypotension.
- Advise patient to consult health care professional before taking any cough, cold, or allergy remedies.
- Instruct patient to notify health care professional of medication regimen before any surgery, especially cataract surgery.
- Advise patient to notify health care professional if priapism, angina, frequent dizziness, rash, or fainting occurs.
- Emphasize the importance of follow-up exams to evaluate effectiveness of medication.
- Assess risk for falls; implement fall prevention program and instruct patient and family in preventing falls at home.

al-FYOO-zo-sin

NDC Code

13668- Torrent Pharmaceuticals Limited
- 13668-021- ALFUZOSIN HYDROCHLORIDE
  - 13668-021-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-01)

13668- Torrent Pharmaceuticals Limited
- 13668-021- ALFUZOSIN HYDROCHLORIDE
  - 13668-021-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-05)

13668- Torrent Pharmaceuticals Limited
- 13668-021- ALFUZOSIN HYDROCHLORIDE
  - 13668-021-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (13668-021-30)

13668- Torrent Pharmaceuticals Limited
- 13668-021- ALFUZOSIN HYDROCHLORIDE
  - 13668-021-64- 90 TABLET, EXTENDED RELEASE in 1 DOSE PACK (13668-021-64)

29300- Unichem Pharmaceuticals (USA), Inc.
- 29300-155- Alfuzosin hydrochloride
  - 29300-155-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-01)

29300- Unichem Pharmaceuticals (USA), Inc.
- 29300-155- Alfuzosin hydrochloride
  - 29300-155-13- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-13)

29300- Unichem Pharmaceuticals (USA), Inc.
- 29300-155- Alfuzosin hydrochloride
  - 29300-155-19- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (29300-155-19)

33261- Aidarex Pharmaceuticals LLC
- 33261-994- Alfuzosin Hydrochloride
  - 33261-994-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-30)

33261- Aidarex Pharmaceuticals LLC
- 33261-994- Alfuzosin Hydrochloride
  - 33261-994-60- 60 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-60)

33261- Aidarex Pharmaceuticals LLC
- 33261-994- Alfuzosin Hydrochloride
  - 33261-994-90- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (33261-994-90)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-746- Alfuzosin Hydrochloride
  - 43353-746-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (43353-746-30)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-746- Alfuzosin Hydrochloride
  - 43353-746-60- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (43353-746-60)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-945- Alfuzosin hydrochloride
  - 43353-945-16- 6000 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-16)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-945- Alfuzosin hydrochloride
  - 43353-945-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-30)

43353- Aphena Pharma Solutions - Tennessee, LLC
- 43353-945- Alfuzosin hydrochloride
  - 43353-945-60- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (43353-945-60)

47335- Sun Pharmaceutical Industries, Inc.
- 47335-956- Alfuzosin Hydrochloride
  - 47335-956-08- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-08)

47335- Sun Pharmaceutical Industries, Inc.
- 47335-956- Alfuzosin Hydrochloride
  - 47335-956-18- 1000 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-18)

47335- Sun Pharmaceutical Industries, Inc.
- 47335-956- Alfuzosin Hydrochloride
  - 47335-956-81- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-81)

47335- Sun Pharmaceutical Industries, Inc.
- 47335-956- Alfuzosin Hydrochloride
  - 47335-956-83- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-83)

47335- Sun Pharmaceutical Industries, Inc.
- 47335-956- Alfuzosin Hydrochloride
  - 47335-956-88- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (47335-956-88)

55648- Wockhardt Limited
- 55648-738- Alfuzosin Hydrochloride
  - 55648-738-01- 30 TABLET in 1 BOTTLE (55648-738-01)

55648- Wockhardt Limited
- 55648-738- Alfuzosin Hydrochloride
  - 55648-738-02- 100 TABLET in 1 BOTTLE (55648-738-02)

55648- Wockhardt Limited
- 55648-738- Alfuzosin Hydrochloride
  - 55648-738-03- 500 TABLET in 1 BOTTLE (55648-738-03)

55648- Wockhardt Limited
- 55648-738- Alfuzosin Hydrochloride
  - 55648-738-05- 10 BLISTER PACK in 1 CARTON (55648-738-05) > 10 TABLET in 1 BLISTER PACK

57237- Rising Health, LLC
- 57237-114- Alfuzosin Hydrochloride
  - 57237-114-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-01)

57237- Rising Health, LLC
- 57237-114- Alfuzosin Hydrochloride
  - 57237-114-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-05)

57237- Rising Health, LLC
- 57237-114- Alfuzosin Hydrochloride
  - 57237-114-90- 90 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (57237-114-90)

59212- Concordia Pharmaceuticals Inc.
- 59212-200- Uroxatral
  - 59212-200-10- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (59212-200-10)

59212- Concordia Pharmaceuticals Inc.
- 59212-200- Uroxatral
  - 59212-200-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (59212-200-30)

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-0- 10 BLISTER PACK in 1 CARTON (60505-2850-0) > 10 TABLET, EXTENDED RELEASE in 1 BLISTER PACK

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-1- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-1)

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-3- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-3)

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-5- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-5)

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-7- 8000 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-7)

60505- Apotex Corp.
- 60505-2850- Alfuzosin Hydrochloride
  - 60505-2850-8- 1000 TABLET, EXTENDED RELEASE in 1 BOTTLE (60505-2850-8)

63629- Bryant Ranch Prepack
- 63629-7907- Alfuzosin hydrochloride
  - 63629-7907-1- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (63629-7907-1)

64679- Wockhardt USA LLC.
- 64679-738- Alfuzosin Hydrochloride
  - 64679-738-01- 30 TABLET in 1 BOTTLE (64679-738-01)

64679- Wockhardt USA LLC.
- 64679-738- Alfuzosin Hydrochloride
  - 64679-738-02- 100 TABLET in 1 BOTTLE (64679-738-02)

64679- Wockhardt USA LLC.
- 64679-738- Alfuzosin Hydrochloride
  - 64679-738-03- 500 TABLET in 1 BOTTLE (64679-738-03)

64679- Wockhardt USA LLC.
- 64679-738- Alfuzosin Hydrochloride
  - 64679-738-05- 10 BLISTER PACK in 1 CARTON (64679-738-05) > 10 TABLET in 1 BLISTER PACK

65862- Aurobindo Pharma Limited
- 65862-249- Alfuzosin Hydrochloride
  - 65862-249-01- 100 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-01)

65862- Aurobindo Pharma Limited
- 65862-249- Alfuzosin Hydrochloride
  - 65862-249-05- 500 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-05)

65862- Aurobindo Pharma Limited
- 65862-249- Alfuzosin Hydrochloride
  - 65862-249-30- 30 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-30)

65862- Aurobindo Pharma Limited
- 65862-249- Alfuzosin Hydrochloride
  - 65862-249-90- 90 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-90)

65862- Aurobindo Pharma Limited
- 65862-249- Alfuzosin Hydrochloride
  - 65862-249-99- 1000 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (65862-249-99)

69097- Cipla USA Inc.
- 69097-844- Alfuzosin Hydrochloride extended release
  - 69097-844-02- 30 TABLET in 1 BOTTLE (69097-844-02)

69097- Cipla USA Inc.
- 69097-844- Alfuzosin Hydrochloride extended release
  - 69097-844-05- 90 TABLET in 1 BOTTLE (69097-844-05)

69097- Cipla USA Inc.
- 69097-844- Alfuzosin Hydrochloride extended release
  - 69097-844-07- 100 TABLET in 1 BOTTLE (69097-844-07)

69097- Cipla USA Inc.
- 69097-844- Alfuzosin Hydrochloride extended release
  - 69097-844-12- 500 TABLET in 1 BOTTLE (69097-844-12)

70934- Denton Pharma, Inc. DBA Northwind Pharmaceuticals
- 70934-306- Alfuzosin Hydrochloride
  - 70934-306-30- 30 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (70934-306-30)

76282- Exelan Pharmaceuticals Inc.
- 76282-302- Alfuzosin hydrochloride
  - 76282-302-01- 100 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-01)

76282- Exelan Pharmaceuticals Inc.
- 76282-302- Alfuzosin hydrochloride
  - 76282-302-05- 500 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-05)

76282- Exelan Pharmaceuticals Inc.
- 76282-302- Alfuzosin hydrochloride
  - 76282-302-90- 90 TABLET, EXTENDED RELEASE in 1 BOTTLE (76282-302-90)

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

Code ⬆