vibegron

REMS

Treatment of symptoms of overactive bladder (OAB) including urge urinary incontinence, urgency, and frequency.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity;
End-stage renal disease;
Severe hepatic impairment.

Use Cautiously in:

Bladder outlet obstruction/concurrent antimuscarinics (↑ risk of urinary retention);
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: nasopharyngitis, upper respiratory tract infection

GI: constipation, diarrhea, dry mouth, nausea

GU: urinary retention, urinary tract infection

Neuro: headache

Resp: bronchitis

Interactions ⬆ ⬇

Drug-drug:

May ↑ levels and risk of toxicity of digoxin; closely monitor serum digoxin concentrations.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

PO (Adults ): 75 mg once daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

As a selective beta-3 adrenergic agonist, it relaxes the detrusor smooth muscles, which increases bladder capacity during storage phase of bladder fill-void cycle.

Therapeutic effects:

Reduction in OAB symptoms.

Classifications ⬆ ⬇

Therapeutic Classification: urinary tract antispasmodics

Pharmacologic Classification: beta-adrenergic agonists

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Extensively distributed to extravascular tissues.

Metabolism/Excretion: Some metabolism in liver via CYP3A4 isoenzyme. Primarily excreted in feces (59%; 54% as unchanged drug), with 20% excreted in urine (19% as unchanged drug).

Half-Life: 30.8 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	1–3 hr	24 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take vibegron as directed. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Advise patient to notify health care professional if urinary retention (cannot empty bladder) occurs or if constipation persists. Discuss methods of preventing constipation, such as increasing dietary bulk, increasing fluid intake, and increasing mobility.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇