le-FLU-noe-mide
Contraindicated in:
Use Cautiously in:
Exercise Extreme Caution in:
CV: chest pain, hypertension
Derm: alopecia, rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), dry skin, eczema, pruritus, skin ulcers, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: pharyngitis, rhinitis, sinusitis
F and E: hypokalemia
GI: diarrhea, nausea, ↑liver enzymes, abdominal pain, anorexia, dyspepsia, gastroenteritis, HEPATOTOXICITY, HEPATOTOXICITY, mouth ulcers, vomiting
MS: arthralgia, back pain, joint disorder, leg cramps, synovitis, tenosynovitis
Neuro: headache, dizziness, paresthesia, peripheral neuropathy, weakness
Resp: bronchitis, cough, ILD, pneumonia
Misc: INFECTION (INCLUDING SEPSIS AND TUBERCULOSIS [TB] REACTIVATION)
Drug-drug:
Therapeutic Classification: antirheumatics (DMARDs)
Pharmacologic Classification: immune response modifiers, pyrimidine synthesis inhibitors
Absorption: 80% absorbed following oral administration.
Distribution: Well distributed to tissues.
Protein Binding: 99%.
Half-Life: 14–18 days.
(antirheumatic effect)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 1 mo | 3–6 mo | wk–mos‡ |
‡Due to persistence of active metabolite.
le-FLU-noe-mide
NDC Code