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Indications ⬇

REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, hypotension

Derm: pruritus, rash

EENT: nasal congestion, tinnitus

GI: nausea, constipation

GU: frequency

Metab: ↑weight, hyperglycemia

Neuro: dizziness, drowsiness, fatigue, weakness, ataxia, confusion, depression, headache, insomnia, SEIZURES (IT)

Misc: hypersensitivity reactions, sweating

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Fleqsuvy, Gablofen, Lioresal, Lyvispah, Ozobax

Action ⬆ ⬇

  • Inhibits reflexes at the spinal level.
Therapeutic effects:
  • Decreased muscle spasticity; bowel and bladder function may also be improved.

Classifications ⬆ ⬇

Therapeutic Classification: antispasticity agents, skeletal muscle relaxants (centrally acting)

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed; crosses the placenta.

Protein Binding: 30%.

Metabolism/Excretion: 70–80% eliminated unchanged by the kidneys.

Half-Life: 2.5–4 hr.

Time/Action Profile ⬆ ⬇

(effects on spasticity)

ROUTEONSETPEAKDURATION
POhr–wkunknownunknown
IT0.5–1 hr4 hr4–8 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

BAK-loe-fen

Code ⬆

NDC Code