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Indications ⬇

BEERS REMS, High Alert

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: photosensitivity, rash

Endo: hypoglycemia

F and E: hyponatremia

GI: constipation, cramps, diarrhea, dyspepsia, hepatitis, nausea, vomiting

Hemat: agranulocytosis, APLASTIC ANEMIA, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia

Metab: ↑appetite

Neuro: dizziness, drowsiness, headache, weakness

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Glucotrol, Glucotrol XL

Action ⬆ ⬇

  • Lowers blood sugar by stimulating the release of insulin from the pancreas and increasing the sensitivity to insulin at receptor sites.
  • May also decrease hepatic glucose production.
Therapeutic effects:
  • Lowering of blood sugar in diabetic patients.

Classifications ⬆ ⬇

Therapeutic Classification: antidiabetics

Pharmacologic Classification: sulfonylureas

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 2.1–2.6 hr.

Time/Action Profile ⬆ ⬇

(hypoglycemic activity)

ROUTEONSETPEAKDURATION
PO15–30 min1–2 hrup to 24 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

GLIP-i-zide

Code ⬆

NDC Code