section name header

Indications ⬇

REMS


Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypertension, hypotension

Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash

GI: ↑liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), constipation, diarrhea, nausea, vomiting

GU: renal impairment

Hemat: anemia

Local: injection site reactions

MS: ↑creatine kinase

Neuro: dizziness

Resp: dyspnea, EOSINOPHILIC PNEUMONIA

Misc: ANGIOEDEMA, fever

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Complicated Skin/Skin Structure Infections

Renal Impairment

Staphylococcus aureus Bacteremia/Right-Sided Infective Endocarditis

Renal Impairment

Staphylococcus aureus Bacteremia

US Brand Names ⬆ ⬇

Cubicin, Cubicin RF

Action ⬆ ⬇

  • Causes rapid depolarization of membrane potential following binding to bacterial membrane; this results in inhibition of protein, DNA, and RNA synthesis.
Therapeutic effects:
  • Death of bacteria with resolution of infection.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: cyclic lipopeptide antibacterial agents

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Protein Binding: 92%.

Metabolism/Excretion: Metabolism not known; mostly excreted by kidneys.

Half-Life: 8.1 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
IVrapidend of infusion24 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

dap-to-MYE-sin

Code ⬆

NDC Code